and all activities of daily living are gone. Identify the prototype and describe the action, use, adverse effects, contraindications, and nursing implications for centrally acting anticholinergic drugs. Identify the prototype and describe the action, use, adverse effects, contraindications, and nursing implications for the catechol. bromocriptine mesylate (Parlodel). . Assessing for Therapeutic Effects With levodopa and other dopaminergic agents, the nurse observes for improvement in mobility, balance, posture, gait, speech, handwriting, and self-care ability. Comt plays a role in brain metabolism of dopamine and metabolizes approximately 10 of peripheral levodopa. Use in Patients With Hepatic Impairment If liver values are greater than two times the upper limit of normal, discontinuation of tolcapone is necessary.
Patient Teaching Box.2 identifies patient teaching guidelines for levodopa/carbidopa. These drugs, which are not ergot derivatives, may not cause some adverse effects associated with bromocriptine (e.g., pulmonary and peritoneal fibrosis, constriction of coronary arteries). These large amounts increase adverse drug effects. It reaches peak serum levels in 1 to 2 hours and steady-state concentrations within 2 days. Apomorphine hydrochloride (Apokyn) is an antiparkinson agent administered for off time, or off episodes, of Parkinsons diseaseto assist in diminishing the symptoms of hypomobility.
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