by monoamine oxidase. Nelson LS, Lewin NA, Howland MA, Hoffman RS, Goldfrank LR, Flomenbaum NE (2011). 24 34 Besides the sexual transmission of HIV, it may also be transmitted between users who share a common needle. 97 Infants born to methamphetamine-abusing mothers may experience a neonatal withdrawal syndrome, with symptoms involving of abnormal sleep patterns, poor feeding, tremors, and hypertonia. Methamphetamine addiction is largely mediated through increased activation of dopamine receptors and co-localized nmda receptors note 7 in the nucleus accumbens.
DrugFacts: Methamphetamine National Institute on Drug
24 The FDA states that individuals who have experienced hypersensitivity reactions to other stimulants in the past or are currently taking monoamine oxidase inhibitors should not take methamphetamine. 20 According to a National Geographic TV documentary on methamphetamine, an entire subculture known as party and play is based around sexual activity and methamphetamine use. 20 The crash following the use of methamphetamine in this manner is very often severe, with marked hypersomnia (excessive daytime sleepiness). The simplest unsubstituted phenylisopropylamine, 1-phenyl-2-aminopropane, or amphetamine, serves as a common structural template for hallucinogens and psychostimulants. Elevated choline levels, which are indicative of increased cellular membrane synthesis and turnover are also evident in the frontal gray matter of meth abusers (Ernst., 2000; Salo., quantitative Research Critique 2007; Taylor., 2007). Subsequent oxidation at the benzylic position by DA -hydroxylase affords p -hydroxynorephedrine.